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ACE2, angiotensin-(1-7), and Mas: the other side of the coin

Item Type:Review
Title:ACE2, angiotensin-(1-7), and Mas: the other side of the coin
Creators Name:Bader, M.
Abstract:The renin–angiotensin system (RAS) has recently been extended by the addition of a novel axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide angiotensin (1–7) (Ang-(1–7)), and the G protein-coupled receptor Mas. ACE2 converts the vasoconstrictive and pro-oxidative peptide angiotensin II (Ang II) into Ang-(1–7) which exerts vasodilatory and antioxidative effects via its receptor Mas. Thereby, ACE2 regulates the local actions of the RAS in cardiovascular tissues and the ACE2/Ang-(1–7)/Mas axis exerts protective actions in hypertension, diabetes, and other cardiovascular disorders. Consequently, this novel RAS axis represents a promising therapeutic target for cardiovascular and metabolic diseases. This article is published as part of the special issue on the Renin-Angiotensin System.
Keywords:Angiotensin I, Angiotensin III, Brain, G-Protein-Coupled Receptors, Gene Expression, Kidney, Lung, Myocardium, Peptide Fragments, Peptidyl-Dipeptidase A, Proto-Oncogene Proteins, Renin-Angiotensin System, Animals
Source:Pfluegers Archiv European Journal of Physiology
ISSN:0031-6768
Publisher:Springer (Germany)
Volume:465
Number:1
Page Range:79-85
Date:January 2013
Official Publication:https://doi.org/10.1007/s00424-012-1120-0
PubMed:View item in PubMed

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