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Visualizing brain inflammation with a shingled-leg radio-frequency head probe for (19)F/(1)H MRI

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Item Type:Article
Title:Visualizing brain inflammation with a shingled-leg radio-frequency head probe for (19)F/(1)H MRI
Creators Name:Waiczies, H. and Lepore, S. and Drechsler, S. and Qadri, F. and Purfürst, B. and Sydow, K. and Dathe, M. and Kühne, A. and Lindel, T. and Hoffmann, W. and Pohlmann, A. and Niendorf, T. and Waiczies, S.
Abstract:Magnetic resonance imaging (MRI) provides the opportunity of tracking cells in vivo. Major challenges in dissecting cells from the recipient tissue and signal sensitivity constraints albeit exist. In this study, we aimed to tackle these limitations in order to study inflammation in autoimmune encephalomyelitis. We constructed a very small dual-tunable radio frequency (RF) birdcage probe tailored for (19)F (fluorine) and (1)H (proton) MR mouse neuroimaging. The novel design eliminated the need for extra electrical components on the probe structure and afforded a uniform -field as well as good SNR. We employed fluorescently-tagged (19)F nanoparticles and could study the dynamics of inflammatory cells between CNS and lymphatic system during development of encephalomyelitis, even within regions of the brain that are otherwise not easily visualized by conventional probes. (19)F/(1)H MR Neuroimaging will allow us to study the nature of immune cell infiltration during brain inflammation over an extensive period of time.
Keywords:Brain, Autoimmune Experimental Encephalomyelitisc, Equipment Design, Fluorine, Magnetic Resonance Imaging, Nanoparticles, Neuroimaging, Protons, Animals, Mice
Source:Scientific Reports
ISSN:2045-2322
Publisher:Nature Publishing Group (U.K.)
Volume:3
Page Range:1280
Date:15 February 2013
Official Publication:https://doi.org/10.1038/srep01280
PubMed:View item in PubMed

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