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Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

Item Type:Article
Title:Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Creators Name:Chekulaeva, M. and Filipowicz, W.
Abstract:MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.
Keywords:Biological Models, Cells, Gene Expression Regulation, Messenger RNA, MicroRNAs, Post-Transcriptional RNA Processing, Animals
Source:Current Opinion in Cell Biology
Publisher:Elsevier / Current Biology
Page Range:452-460
Date:June 2009
Official Publication:https://doi.org/10.1016/j.ceb.2009.04.009
PubMed:View item in PubMed

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