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The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis

Item Type:Review
Title:The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis
Creators Name:Schreiber, A. and Kettritz, R.
Abstract:Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were developed to study ANCA-neutrophil interactions in complex in vivo situations. We not only discuss the significance of ANCA-neutrophil interactions for disease induction but also how a detailed understanding of these interactions helps to identify novel treatment targets for ANCA vasculitis.
Keywords:Inflammation, ANCA, Animal Model, Crescentic Glomerulonephritis, Animals
Source:Journal of Leukocyte Biology
ISSN:0741-5400
Publisher:Society for Leukocyte Biology (U.S.A.)
Volume:94
Number:4
Page Range:623-631
Date:October 2013
Official Publication:https://doi.org/10.1189/jlb.1012525
PubMed:View item in PubMed

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