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CXCL5 limits macrophage foam cell formation in atherosclerosis

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Official URL:https://doi.org/10.1172/JCI66580
PubMed:View item in PubMed
Creators Name:Rousselle, A. and Qadri, F. and Leukel, L. and Yilmaz, R. and Fontaine, J.F. and Sihn, G. and Bader, M. and Ahluwalia, A. and Duchene, J.
Journal Title:Journal of Clinical Investigation
Journal Abbreviation:J Clin Invest
Page Range:1343-1347
Date:1 March 2013
Keywords:ATP-Binding Cassette Transporters, Aorta, Apolipoproteins E, Atherosclerotic Plaque, Atherosclerosis, Chemokine CXCL5, Cholesterol, Endothelial Cells, Foam Cells, Inbred C57BL Mice, Interleukin-8B Receptors, Knockout Mice, Macrophage Activation, Messenger RNA, Transcriptional Activation, Up-Regulation, Animals, Mice
Abstract:The ELR+-CXCL chemokines have been described typically as potent chemoattractants and activators of neutrophils during the acute phase of inflammation. Their role in atherosclerosis, a chronic inflammatory vascular disease, has been largely unexplored. Using a mouse model of atherosclerosis, we found that CXCL5 expression was upregulated during disease progression, both locally and systemically, but was not associated with neutrophil infiltration. Unexpectedly, inhibition of CXCL5 was not beneficial but rather induced a significant macrophage foam cell accumulation in murine atherosclerotic plaques. Additionally, we demonstrated that CXCL5 modulated macrophage activation, increased expression of the cholesterol efflux regulatory protein ABCA1, and enhanced cholesterol efflux activity in macrophages. These findings reveal a protective role for CXCL5, in the context of atherosclerosis, centered on the regulation of macrophage foam cell formation.
Publisher:American Society for Clinical Investigation (U.S.A.)
Item Type:Article

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