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Activating autoantibodies against the AT1-receptor in vascular disease

Item Type:Article
Title:Activating autoantibodies against the AT1-receptor in vascular disease
Creators Name:Dechend, R. and Dragun, D. and Herse, F. and Riemekasten, G. and Schulze-Forster, K. and Mueller, D.N. and Heidecke, H.
Abstract:Activating autoantibodies to the angiotensin II type I receptor (AT1-AA) have been described in different vascular diseases: preeclampsia, non HLA-mediated transplantat rejection and systemic sclerosis. All three diseases are characterised by severe obliterative, inflammatory vasculopathy with a prominent autoimmune background. AT1-AA were described 12 years ago in preeclampsia. Preeclampsia is a common, pregnancy- induced disorder, consisting of hypertension and proteinuria in the last trimester. The condition is one of the leading causes for maternal and perinatal morbidity and mortality. An observation of a patient with transplant rejection without HLA antibodies and a preeclampsia in her medical history, let to the discovery of AT1-AA in these patients. Until then we relied on a subjective, time consuming bioassay to detect AT1-AA. The establishment and validation of a cell-based ELISA facilitated research on AT1-AA immensely. Recently, AT1-AA were found in patients with systemic sclerosis.
Keywords:AT1-Receptor, AT1-AA, Preeclampsia, Transplant Rejection, Systemic Sclerosis
Source:Transplantationsmedizin
ISSN:0946-9648
Publisher:Pabst Science Publishers (Germany)
Volume:24
Number:1
Page Range:20-26
Date:2012
Official Publication:http://www.transplantation.de/748.html

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