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Wnt signaling in stem and cancer stem cells

Item Type:Article
Title:Wnt signaling in stem and cancer stem cells
Creators Name:Holland, J.D. and Klaus, A. and Garratt, A.N. and Birchmeier, W.
Abstract:The functional versatility of Wnt/{beta}-catenin signaling can be seen by its ability to act in stem cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis, stem cells demonstrate a requirement for {beta}-catenin in mediating the response to Wnt signaling for their maintenance and transition from a pluripotent state. In adult stem cells, Wnt signaling functions at various hierarchical levels to contribute to specification of different tissues. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signaling in stem and progenitor cells is subverted in cancer cells to allow malignant progression. Intensive work is currently being performed to resolve how intrinsic and extrinsic factors that regulate Wnt/{beta}-catenin signaling coordinate the stem and cancer stem cell states.
Keywords:Beta Catenin, Genetic Transcription, Hematopoietic System, Human Mammary Glands, Induced Pluripotent Stem Cells, Intestines, Mammalian Embryo, Neoplastic Cell Transformation, Neoplastic Stem Cells, Nervous System, Pluripotent Stem Cells, Skin, Stem Cells, Sumoylation, Ubiquitination, Wnt Proteins, Wnt Signaling Pathway, Animals
Source:Current Opinion in Cell Biology
Publisher:Elsevier / Current Biology
Page Range:254-264
Date:April 2013
Official Publication:https://doi.org/10.1016/j.ceb.2013.01.004
PubMed:View item in PubMed

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