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(Pro)renin receptor: subcellular localizations and functions

Item Type:Article
Title:(Pro)renin receptor: subcellular localizations and functions
Creators Name:Sihn, G. and Burckle, C. and Rousselle, A. and Reimer, T. and Bader, M.
Abstract:Since its first report in 1996, the concept of the so-called (Pro)renin receptor ((P)RR/ATP6ap2) has dramactically evolved from a receptor mediating cellular effects of (pro)renin, to a protein with more basic and potentially essential intracellular functions. Among the arguments urging to reconsider the role of (P)RR was the observation that its localization appears mainly intracellular, although this does not preclude potential functions at the cell surface. However, despite about 10 years of research boosted by the generation of genetically modified animal models, the basic mechanisms of action of this protein at the cellular level remain elusive. This review aims at discussing the functions described for (P)RR in relation to its subcellular localization(s).
Keywords:(Pro)Renin Receptor, Renin-Angiotensin System, Vacuolar H+- ATPase, Wnt Signaling, Autophagy, Animals, Mice
Source:Frontiers in Bioscience
ISSN:1093-9946
Publisher:Frontiers in Bioscience (U.S.A.)
Volume:5
Page Range:500-508
Date:1 January 2013
Official Publication:https://doi.org/10.2741/E631
PubMed:View item in PubMed

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