Helmholtz Gemeinschaft


Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney

Item Type:Review
Title:Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney
Creators Name:Kassmann, M. and Harteneck, C. and Zhu, Z. and Nürnberg, B. and Tepel, M. and Gollasch, M.
Abstract:Recent pre-clinical data indicate that activators of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) may improve the outcome of ischemic acute kidney injury (AKI). The underlying mechanisms are unclear, but may involve TRPV1 channels in dorsal root ganglion neurons that innervate several tissues including kidney. Recent data identified TRPV4, together with TRPV1, to serve as major calcium influx channels in endothelial cells. In these cells, gating of individual TRPV4 channels within a four-channel cluster provides elementary calcium influx (calcium sparklets) to open calcium-activated potassium channels and promote vasodilation. The TRPV receptors can also form heteromers that exhibit unique conductance and gating properties, further increasing their spatio-functional diversity. This review summarizes data on electrophysiological properties of TRPV1/4 and their modulation by endogenous channel agonists, phospolipase C and phosphatidylinositide 3-kinase (PI3 kinase). We review important roles of TRPV1 and TRPV4 in kidney physiology and renal ischemia reperfusion injury; further studies are warranted to address renoprotective mechanism of vanilloid receptors in ischemic AKI including the role of the capsaicin receptor TRPV1 in primary sensory nerves and/or endothelium. Particular attention should be paid to understand the kidneys' ability to respond to ischemic stimuli after catheter-based renal denervation therapy in man whereas the discovery of novel pharmacological TRPV modulators may be a successful strategy for better treatment of acute or chronic kidney failure.
Keywords:TRP Channels, Hyperforin, Renal Endothelium, No Reflow Phenomenon, Sparklets, Dorsal Root Ganglion Neurons, Endothelial Relaxation, Calcium Homeostasis, Renal Denervation Therapy, Animals
Source:Acta Physiologica
Page Range:546-564
Date:March 2013
Official Publication:https://doi.org/10.1111/apha.12051
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library