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Prognostic factors in Wegener's granulomatosis

Item Type:Article
Title:Prognostic factors in Wegener's granulomatosis
Creators Name:Briedigkeit, L. and Kettritz, R. and Goebel, U. and Natusch, R.
Abstract:We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multiple organs in 49 (77%) patients. Renal biopsies were obtained in 33 patients; 13 (39%) had extracapillary glomerulonephritis, which was the most common renal lesion. All but three patients received immunosuppressive therapy. At time of follow-up, 17 (27%) patients were in complete, and 26 (40%) in partial remission. We employed a Kaplan Meier analysis to identify predictor variables of outcome. Renal involvement, initial creatinine concentration, serum albumin or total protein concentration, leukocyte count and erythrocyturia proved to be predictor variables. These variables may be of value in guiding the intensity of treatment in patients with Wegener's granulomatosis.
Keywords:Granulomatosis with Polyangiitis, Immunotherapy, Kidney, Prognosis, Retrospective Studies, Risk Factors
Source:Postgraduate Medical Journal
Page Range:856-861
Date:November 1993
Official Publication:https://doi.org/10.1136/pgmj.69.817.856
PubMed:View item in PubMed

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