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Endocytic receptor-mediated control of morphogen signaling

Item Type:Article
Title:Endocytic receptor-mediated control of morphogen signaling
Creators Name:Willnow, T.E. and Christ, A. and Hammes, A.
Abstract:Receptor-mediated endocytosis provides a mechanism by which cells take up signaling molecules from the extracellular space. Recent studies have shown that one class of endocytic receptors, the low-density lipoprotein receptor-related proteins (LRPs), is of particular relevance for embryonic development. In this Primer, we describe how LRPs constitute central pathways that modulate morphogen presentation to target tissues and cellular signal reception, and how LRP dysfunction leads to developmental disturbances in many species.
Keywords:LDL Receptor-Related Proteins, Endocytosis, Morphogens, Animals
Source:Development
ISSN:0950-1991
Publisher:Company of Biologists (U.K.)
Volume:139
Number:23
Page Range:4311-4319
Date:1 December 2012
Official Publication:https://doi.org/10.1242/dev.084467
PubMed:View item in PubMed

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