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Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains

Item Type:Article
Title:Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains
Creators Name:Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Abstract:A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to "turn off" the activity of target proteins and to label them covalently. Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research.
Keywords:Phosphotyrosine Isosters, Photoaffinity Labeling, Photochemistry, Proteins, Protein Tyrosine Phosphatases
Source:Angewandte Chemie International Edition
ISSN:1433-7851
Publisher:Wiley-VCH (Germany)
Volume:51
Number:37
Page Range:9441-9447
Date:10 September 2012
Official Publication:https://doi.org/10.1002/anie.201201475
PubMed:View item in PubMed

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