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Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains

Official URL:https://doi.org/10.1002/anie.201201475
PubMed:View item in PubMed
Creators Name:Horatscheck, A. and Wagner, S. and Ortwein, J. and Kim, B.G. and Lisurek, M. and Beligny, S. and Schuetz, A. and Rademann, J.
Journal Title:Angewandte Chemie International Edition
Journal Abbreviation:Angew Chem Int Edit
Volume:51
Number:37
Page Range:9441-9447
Date:10 September 2012
Keywords:Phosphotyrosine Isosters, Photoaffinity Labeling, Photochemistry, Proteins, Protein Tyrosine Phosphatases
Abstract:A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to "turn off" the activity of target proteins and to label them covalently. Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research.
ISSN:1433-7851
Publisher:Wiley-VCH (Germany)
Item Type:Article

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