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Chloride in vesicular trafficking and function

Item Type:Review
Title:Chloride in vesicular trafficking and function
Creators Name:Stauber, T. and Jentsch, T.J.
Abstract:Luminal acidification is of pivotal importance for the physiology of the secretory and endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V-ATPase requires charge compensation by counterion currents that are commonly attributed to chloride. The molecular identification of intracellular chloride transporters and the improvement of methodologies for measuring intraorganellar pH and chloride have facilitated the investigation of the physiology of vesicular chloride transport. New data question the requirement of chloride for pH regulation of various organelles and furthermore ascribe functions to chloride that are beyond merely electrically shunting the proton pump. This review surveys the currently established and proposed intracellular chloride transporters and gives an overview of membrane-trafficking steps that are affected by the perturbation of chloride transport. Finally, potential mechanisms of membrane-trafficking modulation by chloride are discussed and put into the context of organellar ion homeostasis in general.
Keywords:Channelopathies, Proximal Tubular Endocytosis, Lysosome, Neurotransmitter Uptake, CLC Transporter, CFTR, Animals
Source:Annual Review of Physiology
ISSN:0066-4278
Publisher:Annual Reviews (U.S.A.)
Volume:75
Page Range:453-477
Date:10 February 2013
Official Publication:https://doi.org/10.1146/annurev-physiol-030212-183702
PubMed:View item in PubMed

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