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Cellular reprogramming processes in Drosophila and C. elegans

Item Type:Article
Title:Cellular reprogramming processes in Drosophila and C. elegans
Creators Name:Tursun, B.
Abstract:The identity of individual cell types in a multicellular organism appears to be continuously maintained through active processes but is not irreversible. Changes in the identity of individual cell types can be brought about through ectopic mis-expression of regulatory factors, but in a number of cases also occurs in normal development. I will review here these natural cellular reprogramming processes occurring in the invertebrate model organisms Caenorhabditis elegans and Drosophila melanogaster. Furthermore, I will discuss the issue of why only certain cell types can be converted during induced reprogramming processes evoked by ectopic expression of regulatory factors and how recent work in model systems have shown that this cellular context-dependency can be manipulated.
Keywords:Biological Models, Cellular Reprogramming, Developmental Gene Expression Regulation, Embryonic Development, Epithelial Cells, Transcription Factors, Animals, Caenorhabditis elegans, Drosophila melanogaster
Source:Current Opinion in Genetics & Development
ISSN:0959-437X
Publisher:Current Biology / Elsevier (U.S.A.)
Volume:22
Number:5
Page Range:475-484
Date:October 2012
Official Publication:https://doi.org/10.1016/j.gde.2012.09.005
PubMed:View item in PubMed

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