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The ubiquitin-proteasome system of Saccharomyces cerevisiae

Item Type:Article
Title:The ubiquitin-proteasome system of Saccharomyces cerevisiae
Creators Name:Finley, D. and Ulrich, H.D. and Sommer, T. and Kaiser, P.
Abstract:Protein modifications provide cells with exquisite temporal and spatial control of protein function. Ubiquitin is among the most important modifiers, serving both to target hundreds of proteins for rapid degradation by the proteasome, and as a dynamic signaling agent that regulates the function of covalently bound proteins. The diverse effects of ubiquitylation reflect the assembly of structurally distinct ubiquitin chains on target proteins. The resulting ubiquitin code is interpreted by an extensive family of ubiquitin receptors. Here we review the components of this regulatory network and its effects throughout the cell.
Keywords:Adenosine Triphosphatases, Cell Cycle Proteins, Membrane Proteins, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Protein Transport, Proteolysis, Saccharomyces cerevisiae, Substrate Specificity, Ubiquitin, Ubiquitination
Source:Genetics
ISSN:0016-6731
Publisher:Genetics Society Of America (U.S.A.)
Volume:192
Number:2
Page Range:319-360
Date:1 October 2012
Official Publication:https://doi.org/10.1534/genetics.112.140467
PubMed:View item in PubMed

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