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Detection of broadly expressed neuronal genes in C. elegans

Item Type:Article
Title:Detection of broadly expressed neuronal genes in C. elegans
Creators Name:Ruvinsky, I. and Ohler, U. and Burge, C.B. and Ruvkun, G.
Abstract:The genes that are expressed in most or all types of neurons define generic neuronal features and provide a window into the developmental origin and function of the nervous system. Few such genes (sometimes referred to as pan-neuronal or broadly expressed neuronal genes) have been defined to date and the mechanisms controlling their regulation are not well understood. As a first step in investigating their regulation, we used a computational approach to detect sequences overrepresented in their promoter elements. We identified a ten-nucleotide cis-regulatory motif shared by many broadly expressed neuronal genes and demonstrated that it is involved in control of neuronal expression. Our results further suggest that global and cell-type-specific controls likely act in concert to establish pan-neuronal gene expression. Using the newly discovered motif and genome-level gene expression data, we identified a set of 234 candidate broadly expressed genes. The known involvement of many of these genes in neurogenesis and physiology of the nervous system supports the utility of this set for future targeted analyses.
Keywords:C. elegans, Cis-Regulatory Motifs, Gene Expression, Pan-Neuronal Genes
Source:Developmental Biology
Publisher:Academic Press
Page Range:617-626
Date:15 February 2007
Official Publication:https://doi.org/10.1016/j.ydbio.2006.09.014
PubMed:View item in PubMed

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