Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery

Item Type:Article
Title:The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery
Creators Name:Parry, T.J. and Theisen, J.W.M. and Hsu, J.Y. and Wang, Y.L. and Corcoran, D.L. and Eustice, M. and Ohler, U. and Kadonaga, J.T.
Abstract:The TCT motif (polypyrimidine initiator) encompasses the transcription start site of nearly all ribosomal protein genes in Drosophila and mammals. The TCT motif is required for transcription of ribosomal protein gene promoters. The TCT element resembles the Inr (initiator), but is not recognized by TFIID and cannot function in lieu of an Inr. However, a single T-to-A substitution converts the TCT element into a functionally active Inr. Thus, the TCT motif is a novel transcriptional element that is distinct from the Inr. These findings reveal a specialized TCT-based transcription system that is directed toward the synthesis of ribosomal proteins.
Keywords:Core Promoter, Ribosomal Protein Genes, RNA Polymerase II, TFIID
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:24
Number:18
Page Range:2013-2018
Date:15 September 2010
Official Publication:https://doi.org/10.1101/gad.1951110
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library