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Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation

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Item Type:Article
Title:Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation
Creators Name:Lamarca, B. and Speed, J. and Ray, L.F. and Cockrell, K. and Wallukat, G. and Dechend, R. and Granger, J.
Abstract:BACKGROUND: Increases in interleukin 6 (IL-6) and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) are proposed to be important links between placental ischemia and hypertension in preeclampsia. METHODS: The purpose of this study was to determine whether IL-6 (5 ng/day), infused into normal pregnant (NP) rats, increased mean arterial pressure (MAP) and AT1-AA. MAP was analyzed in the presence and absence of an angiotensin type 1 receptor (AT1R) antagonist, losartan, L. RESULTS: MAP and AT1-AA increased from 102 ± 2 to 118 ± 4 mmHg and 0.7 ± 0.3 NP to 14.1 ± 1.4 chronotropic units with chronic IL-6 infusion. MAP responses to IL-6 were abolished in losartan pretreated rats (85 ± 4 in NP + L vs 85 ± 3 mmHg in IL-6 + L). CONCLUSION: These data indicate that IL-6 stimulates AT1-AA and that activation of the AT1R mediates IL-6 induced hypertension during pregnancy.
Keywords:Cytokines, Pregnancy, Hypertension, Renin Angiotensin System, Inflammation, Animals, Rats
Source:International Journal of Interferon, Cytokine and Mediator Research
Publisher:Dove Medical Press
Page Range:65-70
Date:3 November 2011
Official Publication:https://doi.org/10.2147/IJICMR.S22329
PubMed:View item in PubMed

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