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Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals

Item Type:Article
Title:Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on notch signals
Creators Name:Broehl, D. and Vasyutina, E. and Czajkowski, M.T. and Griger, J. and Rassek, C. and Rahn, H.P. and Purfürst, B. and Wende, H. and Birchmeier, C.
Abstract:Skeletal muscle growth and regeneration rely on myogenic progenitor and satellite cells, the stem cells of postnatal muscle. Elimination of Notch signals during mouse development results in premature differentiation of myogenic progenitors and formation of very small muscle groups. Here we show that this drastic effect is rescued by mutation of the muscle differentiation factor MyoD. However, rescued myogenic progenitors do not assume a satellite cell position and contribute poorly to myofiber growth. The disrupted homing is due to a deficit in basal lamina assembly around emerging satellite cells and to their impaired adhesion to myofibers. On a molecular level, emerging satellite cells deregulate the expression of basal lamina components and adhesion molecules like integrin {alpha}7, collagen XVIII{alpha}1, Megf10, and Mcam. We conclude that Notch signals control homing of satellite cells, stimulating them to contribute to their own microenvironment and to adhere to myofibers.
Keywords:Cell Adhesion, Knockout Mice, MyoD Protein, Notch Receptors, Signal Transduction, Skeletal Muscle, Skeletal Muscle Satellite Cells, Animals, Mice
Source:Developmental Cell
Publisher:Cell Press
Page Range:469-481
Date:11 September 2012
Official Publication:https://doi.org/10.1016/j.devcel.2012.07.014
PubMed:View item in PubMed

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