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Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations

Item Type:Article
Title:Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations
Creators Name:Zimmermann, H. and Freing, A. and Kaufhold, F. and Gaede, G. and Bohn, E. and Bock, M. and Oberwahrenbrock, T. and Young, K.L. and Dörr, J. and Wuerfel, J.T. and Schippling, S. and Paul, F. and Brandt, A.U.
Abstract:BACKGROUND: Retinal nerve fibre layer (RNFL) thinning is associated with brain atrophy in multiple sclerosis (MS). An influence of optic neuritis is well documented but sparsely investigated. Recently, the retinal ganglion cell layer (GCL) has been shown to provide superior information regarding visual function and retinal neurodegeneration as compared with RNFL. OBJECTIVE: To investigate the association of white and grey matter brain volume with peripapillary RNFL and macular GCL in MS patients with and without a history of optic neuritis. METHODS: 63 patients with relapsing-remitting MS were included in a two-centre cross-sectional prospective study. All patients underwent retinal examination with spectral domain optical coherence tomography and 1.5 T MRI for determination of normalized brain volume (NBV), white matter volume (NWMV) and grey matter volume (NGMV). RESULTS: Both RNFL and GCL were associated with NBV, NWMV and NGMV in eyes without previous optic neuritis. This association is disrupted in the case of NGMV following optic neuritis. CONCLUSIONS: Both RNFL and GCL as parameters of neuro-axonal damage are comparably linked to whole brain as well as white and grey matter atrophy. An event of optic neuritis interferes with this relation, adding further damage to the optic nerve and disrupting especially an association with grey matter.
Keywords:Relapsing-Remitting Multiple Sclerosis, Optical Coherence Tomography, Brain Atrophy, Retinal Nerve Fibre Layer, Retinal Ganglion Cell Layer, Magnetic Resonance Imaging, Optic Neuritis
Source:Multiple Sclerosis Journal
ISSN:1352-4585
Publisher:Sage Publications (U.K.)
Volume:19
Number:4
Page Range:443-450
Date:April 2013
Official Publication:https://doi.org/10.1177/1352458512457844
PubMed:View item in PubMed

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