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Finding the will and the way of ERAD substrate retrotranslocation

Official URL:https://doi.org/10.1016/j.ceb.2012.05.010
PubMed:View item in PubMed
Creators Name:Hampton, R.Y. and Sommer, T.
Journal Title:Current Opinion in Cell Biology
Journal Abbreviation:Curr Opin Cell Biol
Volume:24
Number:4
Page Range:460-466
Date:August 2012
Keywords:Cytosol, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Proteasome Endopeptidase Complex, Protein Transport, Proteins, Ubiquitin, Ubiquitination, Yeasts
Abstract:ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.
ISSN:0955-0674
Publisher:Current Biology Ltd / Elsevier (U.K.)
Item Type:Review

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