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Finding the will and the way of ERAD substrate retrotranslocation

Item Type:Review
Title:Finding the will and the way of ERAD substrate retrotranslocation
Creators Name:Hampton, R.Y. and Sommer, T.
Abstract:ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.
Keywords:Cytosol, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Proteasome Endopeptidase Complex, Protein Transport, Proteins, Ubiquitin, Ubiquitination, Yeasts
Source:Current Opinion in Cell Biology
Publisher:Elsevier / Current Biology
Page Range:460-466
Date:August 2012
Official Publication:https://doi.org/10.1016/j.ceb.2012.05.010
PubMed:View item in PubMed

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