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Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells

Item Type:Article
Title:Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells
Creators Name:Na, I.K. and Keilholz, U. and Letsch, A. and Bauer, S. and Asemissen, A.M. and Nagorsen, D. and Thiel, E. and Scheibenbogen, C.
Abstract:T-cell trafficking is determined by expression patterns of chemokine receptors. The chemokine receptor CXCR3 is expressed on a subpopulation of type 1 T cells and plays an important role for migration of T cells into inflamed and tumor tissues. Here, we studied the chemokine receptor expression on specific T cells generated against the neoantigen keyhole limpet hemocyanin (KLH) in patients who had been immunized in the context of a tumor peptide vaccination trial with or without the adjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF). In patients immunized in the presence of GM-CSF the fraction of CXCR3(+) KLH-specific T cells was significantly higher than in patients immunized in the absence of GM-CSF (median 45 vs. 20%, P = 0.001). In contrast, the chemokine receptor CCR4, associated with migration to the skin was found in both cohorts on less than 10% of KLH-specific T cells. These results show that CXCR3 expression on vaccine-induced T cells can be modulated by modifying the local vaccine milieu.
Keywords:CXCR3, T Cells, Vaccination, GM-CSF
Source:Cancer Immunology Immunotherapy
ISSN:0340-7004
Publisher:Springer (Germany)
Volume:56
Number:3
Page Range:391-396
Date:March 2007
Official Publication:https://doi.org/10.1007/s00262-006-0198-7
PubMed:View item in PubMed

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