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Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo

Item Type:Article
Title:Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo
Creators Name:Mueller, K. and von Maessenhausen, A. and Aichele, U. and Staerck, L. and Leisegang, M. and Uckert, W. and Pircher, H.
Abstract:The transfer of TCR genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
Keywords:Antigens, CD8-Positive T-Lymphocytes, Cell Membrane, Cytokines, Flow Cytometry, Glycoproteins, Interferon-gamma, Listeria monocytogenes, Lymphocytes, Lymphocytic choriomeningitis virus, Peptide Fragments, Phenotype, Retroviridae, Spleen, T-Cell Antigen Receptors, Viral Antigens, Viral Proteins, Animals, Mice
Source:Journal of Virology
ISSN:0022-538X
Publisher:American Society for Microbiology (U.S.A.)
Volume:86
Number:19
Page Range:10866-10869
Date:October 2012
Official Publication:https://doi.org/10.1128/JVI.01472-12
PubMed:View item in PubMed

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