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Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior

Item Type:Article
Title:Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior
Creators Name:Warner-Schmidt, J.L. and Schmidt, E.F. and Marshall, J.J. and Rubin, A.J. and Arango-Lievano, M. and Kaplitt, M.G. and Ibanez-Tallon, I. and Heintz, N. and Greengard, P.
Abstract:A large number of studies have demonstrated that the nucleus accumbens (NAC) is a critical site in the neuronal circuits controlling reward responses, motivation, and mood, but the neuronal cell type(s) underlying these processes are not yet known. Identification of the neuronal cell types that regulate depression-like states will guide us in understanding the biological basis of mood and its regulation by diseases like major depressive disorder. Taking advantage of recent findings demonstrating that the serotonin receptor chaperone, p11, is an important molecular regulator of depression-like states, here we identify cholinergic interneurons (CINs) as a primary site of action for p11 in the NAC. Depression-like behavior is observed in mice after decrease of p11 levels in NAC CINs. This phenotype is recapitulated by silencing neuronal transmission in these cells, demonstrating that accumbal cholinergic neuronal activity regulates depression-like behaviors and suggesting that accumbal CIN activity is crucial for the regulation of mood and motivation.
Keywords:Aacetylcholine, Neurotransmission, s100a10, Antidepressant, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:109
Number:28
Page Range:11360-11365
Date:10 July 2012
Official Publication:https://doi.org/10.1073/pnas.1209293109
PubMed:View item in PubMed

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