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Prorenin receptor regulates more than the renin-angiotensin system

Item Type:Review
Title:Prorenin receptor regulates more than the renin-angiotensin system
Creators Name:Mueller, D.N. and Binger, K.J. and Riediger, F.
Abstract:The (pro)renin receptor (PRR) was initially believed to be a contributor to the pathogenesis of cardiovascular diseases via the amplification of renin- or prorenin-induced angiotensin (Ang) formation. However, a recent paradigm shift suggests a new role for PRR, separate from the renin-angiotensin system (RAS), in contributing to cellular homeostasis. Specifically, PRR is thought to be essential for vacuolar H(+)-ATPase (V-ATPase) activity and acts as an adaptor between the V-ATPase and the Wnt signalling pathway. Recent PRR conditional knock-out studies have confirmed this link between V-ATPase and PRR, with deletion resulting in the accumulation of autophagic vacuoles and animal lethality. The molecular mechanism by which PRR contributes to V-ATPase activity, and whether multiple signalling pathways are affected by PRR loss, is currently unknown. Additionally, cleavage by furin at a single site within full-length PRR results in the production of a soluble form of the receptor, which is detectable in plasma. Soluble PRR is hypothesized to bind to specific ligands and receptors and mediate signal transduction pathways. Understanding the physiological function of full-length and soluble PRR will be important for establishing its role in pathology.
Keywords:Prorenin Receptor, Renin-Angiotensin System, V-ATPase, Wnt Signalling, Animals
Source:Annals of Medicine
Publisher:Informa Healthcare
Number:Suppl 1
Page Range:S43-S48
Date:June 2012
Official Publication:https://doi.org/10.3109/07853890.2012.660496
PubMed:View item in PubMed

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