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Reliability of fasting plasma alkylresorcinol metabolites concentrations measured 4 months apart

Item Type:Article
Title:Reliability of fasting plasma alkylresorcinol metabolites concentrations measured 4 months apart
Creators Name:Montonen, J. and Landberg, R. and Kamal-Eldin, A. and Aman, P. and Boeing, H. and Steffen, A. and Pischon, T.
Abstract:Alkylresorcinols (AR) have been suggested as specific dietary biomarkers of whole-grain wheat and rye intake. AR are metabolised to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have longer apparent half-lives and were recently proposed to better reflect long-term whole-grain consumption than the intact AR. The objective of this study was to analyse the reliability-expressed by the intraclass correlation coefficient (ICC)-of AR metabolite concentrations among 100 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study who provided two fasting plasma samples 4 months apart. DHBA and DHPPA concentrations were not significantly different between the first and second measurement over the 4-month period (P>0.05). The ICC was 0.32 (95% confidence interval (CI)=0.13-0.49) for DHBA and 0.37 (95%CI=0.19-0.53) for DHPPA. These results suggest that AR metabolites cannot be considered to be better biomarkers of whole-grain wheat and rye intake than the intact AR in fasting plasma (ICC=0.42).
Keywords:Alkylresorcinols, DHBA, DHPPA, Biomarker, Reliability, Whole-Grain
Source:European Journal of Clinical Nutrition
ISSN:0954-3007
Publisher:Nature Publishing Group (U.K.)
Volume:66
Number:8
Page Range:968-970
Date:August 2012
Official Publication:https://doi.org/10.1038/ejcn.2012.66
PubMed:View item in PubMed

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