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Involvement of claudins in zebrafish brain ventricle morphogenesis

Item Type:Article
Title:Involvement of claudins in zebrafish brain ventricle morphogenesis
Creators Name:Zhang, J. and Liss, M. and Wolburg, H. and Blasig, I.E. and Abdelilah-Seyfried, S.
Abstract:Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
Keywords:Brain Ventricle Morphogenesis, Tight Junction, Claudin-5a, Claudin-3, Animals, Zebrafish
Source:Annals of the New York Academy of Sciences
Publisher:New York Academy of Sciences
Page Range:193-198
Date:June 2012
Official Publication:https://doi.org/10.1111/j.1749-6632.2012.06507.x
PubMed:View item in PubMed

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