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Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European Cohort

Item Type:Article
Title:Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European Cohort
Creators Name:Schlesinger, S. and Aleksandrova, K. and Pischon, T. and Fedirko, V. and Jenab, M. and Trepo, E. and Boffetta, P. and Dahm, C.C. and Overvad, K. and Tjønneland, A. and Halkjaer, J. and Fagherazzi, G. and Boutron-Ruault, M.C. and Carbonnel, F. and Kaaks, R. and Lukanova, A. and Boeing, H. and Trichopoulou, A. and Bamia, C. and Lagiou, P. and Palli, D. and Grioni, S. and Panico, S. and Tumino, R. and Vineis, P. and Bas Bueno-de-Mesquita, H. and van den Berg, S. and Peeters, P.H.M. and Braaten, T. and Weiderpass, E. and Quirós, J.R. and Travier, N. and Sánchez, M.J. and Navarro, C. and Barricarte, A. and Dorronsoro, M. and Lindkvist, B. and Regner, S. and Werner, M. and Sund, M. and Khaw, K.T. and Wareham, N. and Travis, R.C. and Norat, T. and Wark, P.A. and Riboli, E. and Nöthling, U.
Abstract:General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intra- (IBDC) and extrahepatic bile duct system cancer (EBDSC including gallbladder cancer (GBC)) among 359,525 men and women in the EPIC-study. Hepatitis B and C virus status was measured in a nested case-control sub-set. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC (relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (CI): 2.09-5.87; P(trend) <0.0001) and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13; <0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for liver and gallbladder cancer prevention in Western populations.
Keywords:Liver Neoplasms, Hepatocellular Carcinoma, Biliary Tract Neoplasms, Obesity, Abdominal Fat, Weight Change
Source:International Journal of Cancer
Page Range:645-657
Date:February 2013
Official Publication:https://doi.org/10.1002/ijc.27645
PubMed:View item in PubMed

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