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Meat and fish consumption and risk of pancreatic cancer - results from the european prospective investigation into cancer and nutrition

Item Type:Article
Title:Meat and fish consumption and risk of pancreatic cancer - results from the european prospective investigation into cancer and nutrition
Creators Name:Rohrmann, S. and Linseisen, J. and Nöthlings, U. and Overvad, K. and Egeberg, R. and Tjønneland, A. and Boutron-Ruault, M.C. and Clavel-Chapelon, F. and Cottet, V. and Pala, V. and Tumino, R. and Palli, D. and Panico, S. and Vineis, P. and Boeing, H. and Pischon, T. and Grote, V. and Teucher, B. and Khaw, K.T. and Wareham, N.J. and Crowe, F.L. and Goufa, I. and Orfanos, P. and Trichopoulou, A. and Jeurnink, S.M. and Siersema, P.D. and Peeters, P.H. and Brustad, M. and Engeset, D. and Skeie, G. and Duell, E.J. and Amiano, P. and Barricarte, A. and Molina-Montes, E. and Rodríguez, L. and Tormo, M.J. and Sund, M. and Ye, W. and Lindkvist, B. and Johansen, D. and Ferrari, P. and Jenab, M. and Slimani, N. and Ward, H. and Riboli, E. and Norat, T. and Bas Bueno-de-Mesquita, H.
Abstract:BACKGROUND: Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Included in our analysis were 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000. Until 2008, 865 non-endocrine pancreatic cancer cases have been observed. Calibrated relative risks (RR) and 95% confidence intervals (CI) were computed using multivariable-adjusted Cox Hazard Regression models. RESULTS: The consumption of red meat (RR per 50 g increase per day 1.03, 95% CI 0.93-1.14) and processed meat (RR per 50 g increase per day 0.93, 95% CI 0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day 1.72, 95% CI 1.04-2.84), but there was not association with fish consumption (RR per 50 g increase per day 1.22, 95% CI 0.92-1.62). CONCLUSION: Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings.
Keywords:Meat, Fish, Pancreatic Cancer, Cohort, EPIC, Animals, Fishs, Poultry
Source:International Journal of Cancer
ISSN:0020-7136
Publisher:Wiley-Blackwell (Switzerland)
Volume:132
Number:3
Page Range:617-624
Date:1 February 2013
Official Publication:https://doi.org/10.1002/ijc.27637
PubMed:View item in PubMed

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