Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma

Item Type:	Article
Title:	Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Creators Name:	Zoerner, A.A. and Stichtenoth, D.O. and Engeli, S. and Batkai, S. and Winkler, C. and Schaumann, F. and Janke, J. and Holz, O. and Krug, N. and Tsikas, D. and Jordan, J. and Hohlfeld, J.M.
Abstract:	Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy into different lung segments of patients with allergic asthma. Twenty-four hours later, anandamide concentrations in bronchoalveolar lavage fluids had increased more than fourfold. Anandamide concentrations correlated with severity of airway inflammation. These observations suggest that allergen exposure specifically activates the pulmonary endocannabinoid system (ECS) in patients with allergic asthma.
Keywords:	Allergens, Arachidonic Acids, Asthma, Bronchial Provocation Tests, Bronchoalveolar Lavage Fluid, Cannabinoid Receptor Modulators, Endocannabinoids, Inflammation, Polyunsaturated Alkamides, CB2 Cannabinoid Receptor
Source:	Clinical Pharmacology & Therapeutics
ISSN:	0009-9236
Publisher:	Nature Publishing Group
Volume:	90
Number:	3
Page Range:	388-391
Date:	September 2011
Official Publication:	https://doi.org/10.1038/clpt.2011.94
PubMed:	View item in PubMed

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