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It takes two to tango: IkappaBs, the multifunctional partners of NF-kappaB

Official URL:https://doi.org/10.1111/j.1600-065X.2012.01102.x
PubMed:View item in PubMed
Creators Name:Hinz, M. and Coel Arslan, S. and Scheidereit, C.
Journal Title:Immunological Reviews
Journal Abbreviation:Immunol Rev
Page Range:59-76
Date:March 2012
Keywords:Typical IkappaBs, Atypical IkappaBs, Precursor Proteins, NF-kappaB, Animals
Abstract:The inhibitory IkappaB proteins have been discovered as fundamental regulators of the inducible transcription factor nuclear factor-kappaB (NF-kappaB). As a generally excepted model, stimulus-dependent destruction of inhibitory IkappaBs and processing of precursor molecules, both promoted by components of the signal integrating IkappaB kinase complex, are the key events for the release of various NF-kappaB/Rel dimers and subsequent transcriptional activation. Intense research of more than 20 years provides evidence that the extending family of IkappaBs act not simply as reversible inhibitors of NF-kappaB activation but rather as a complex regulatory module, which assures feedback regulation of the NF-kappaB system and either can inhibit or promote transcriptional activity in a stimulus-dependent manner. Thus, IkappaB and NF-kappaB/Rel family proteins establish a complex interrelationship that allows modulated NF-kappaB-dependent transcription, tailored to the physiological environment.
Publisher:Wiley-Blackwell (Denmark)
Item Type:Review

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