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It takes two to tango: IkappaBs, the multifunctional partners of NF-kappaB

Item Type:Review
Title:It takes two to tango: IkappaBs, the multifunctional partners of NF-kappaB
Creators Name:Hinz, M. and Coel Arslan, S. and Scheidereit, C.
Abstract:The inhibitory IkappaB proteins have been discovered as fundamental regulators of the inducible transcription factor nuclear factor-kappaB (NF-kappaB). As a generally excepted model, stimulus-dependent destruction of inhibitory IkappaBs and processing of precursor molecules, both promoted by components of the signal integrating IkappaB kinase complex, are the key events for the release of various NF-kappaB/Rel dimers and subsequent transcriptional activation. Intense research of more than 20 years provides evidence that the extending family of IkappaBs act not simply as reversible inhibitors of NF-kappaB activation but rather as a complex regulatory module, which assures feedback regulation of the NF-kappaB system and either can inhibit or promote transcriptional activity in a stimulus-dependent manner. Thus, IkappaB and NF-kappaB/Rel family proteins establish a complex interrelationship that allows modulated NF-kappaB-dependent transcription, tailored to the physiological environment.
Keywords:Typical IkappaBs, Atypical IkappaBs, Precursor Proteins, NF-kappaB, Animals
Source:Immunological Reviews
ISSN:0105-2896
Publisher:Wiley-Blackwell (Denmark)
Volume:246
Number:1
Page Range:59-76
Date:March 2012
Official Publication:https://doi.org/10.1111/j.1600-065X.2012.01102.x
PubMed:View item in PubMed

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