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Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality

Item Type:Article
Title:Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality
Creators Name:Purmann, A. and Toedling, J. and Schueler, M. and Carninci, P. and Lehrach, H. and Hayashizaki, Y. and Huber, W. and Sperling, S.
Abstract:In studies of their transcriptional activity, genomes have shown a high order of organization. We assessed the question of how genomically neighboring genes are transcriptionally coupled across tissues and what could be the driving force behind their coupling. We focused our analysis on the transcriptome information for 13 tissues of Mus musculus and 79 tissues of Homo sapiens. The analysis of coexpression patterns of genomically adjacent genes across tissues revealed 2619 and 1275 clusters of highly coexpressed genes, respectively. Most of these clusters consist of pairs and triplets of genes. They span a limited genomic length and are phylogenetically conserved between human and mouse. These clusters consist mainly of nonparalogous genes and show a decreased functional and similar regulatory relationship to one another compared to general genomic neighbors. We hypothesize that these clusters trace back to large-scale, qualitative, persistent reorganizations of the transcriptome, while transcription factor regulation is likely to handle fine-tuning of transcription on shorter time scales. Our data point to so far uncharacterized cis-acting units and reject cofunctionality as a driving force.
Keywords:Genomics, Gene Expression, Mammals, Regulatory Elements, Transcription Regulation, Animals, Mice
Publisher:Academic Press
Page Range:580-587
Date:May 2007
Official Publication:https://doi.org/10.1016/j.ygeno.2007.01.010
PubMed:View item in PubMed

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