Pharmacogenetics and cardiac ion channels

Item Type:	Review
Title:	Pharmacogenetics and cardiac ion channels
Creators Name:	Roepke, T.K. and Abbott, G.W.
Abstract:	Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na(+) and Ca(2+) ion influx, and K(+) ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has seen a leap in our understanding of the molecular genetic origins of inherited cardiac arrhythmia, largely through identification of mutations in cardiac ion channels and the proteins that regulate them. Further, recent advances have shown that 'acquired arrhythmias', which occur more commonly than inherited arrhythmias, arise due to a variety of environmental factors including side effects of therapeutic drugs and often have a significant genetic component. Here, we review the pharmacogenetics of cardiac ion channels-the interplay between genetic and pharmacological factors that underlie human cardiac arrhythmias.
Keywords:	Arrhythmia, HERG, IKr, IKs, KCNE1, KCNE2, KCNQ1, Long QT Syndrome
Source:	Vascular Pharmacology
ISSN:	1537-1891
Publisher:	Elsevier
Volume:	44
Number:	2
Page Range:	90-106
Date:	February 2006
Official Publication:	https://doi.org/10.1016/j.vph.2005.07.013
PubMed:	View item in PubMed

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