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The determinants of tumour immunogenicity

Official URL:https://doi.org/10.1038/nrc3246
PubMed:View item in PubMed
Creators Name:Blankenstein, T. and Coulie, P.G. and Gilboa, E. and Jaffee, E.M.
Journal Title:Nature Reviews Cancer
Journal Abbreviation:Nat Rev Cancer
Volume:12
Number:4
Page Range:307-313
Date:April 2012
Keywords:Cancer Vaccines, Immune System, Immune System Processes, Immunomodulation, Neoplasm Antigens, Neoplasms, Tumor Escape, Animals, Mice
Abstract:Many standard and targeted therapies, as well as radiotherapy, have been shown to induce an anti-tumour immune response, and immunotherapies rely on modulating the host immune system to induce an anti-tumour immune response. However, the immune response to such therapies is often reliant on the immunogenicity of a tumour. Tumour immunogenicity varies greatly between cancers of the same type in different individuals and between different types of cancer. So, what do we know about tumour immunogenicity and how might we therapeutically improve tumour immunogenicity? We asked four leading cancer immunologists around the world for their opinions on this important issue.
ISSN:1474-175X
Publisher:Nature Publishing Group (U.K.)
Item Type:Article

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