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The determinants of tumour immunogenicity

Item Type:Article
Title:The determinants of tumour immunogenicity
Creators Name:Blankenstein, T. and Coulie, P.G. and Gilboa, E. and Jaffee, E.M.
Abstract:Many standard and targeted therapies, as well as radiotherapy, have been shown to induce an anti-tumour immune response, and immunotherapies rely on modulating the host immune system to induce an anti-tumour immune response. However, the immune response to such therapies is often reliant on the immunogenicity of a tumour. Tumour immunogenicity varies greatly between cancers of the same type in different individuals and between different types of cancer. So, what do we know about tumour immunogenicity and how might we therapeutically improve tumour immunogenicity? We asked four leading cancer immunologists around the world for their opinions on this important issue.
Keywords:Cancer Vaccines, Immune System, Immune System Processes, Immunomodulation, Neoplasm Antigens, Neoplasms, Tumor Escape, Animals, Mice
Source:Nature Reviews Cancer
ISSN:1474-175X
Publisher:Nature Publishing Group (U.K.)
Volume:12
Number:4
Page Range:307-313
Date:April 2012
Official Publication:https://doi.org/10.1038/nrc3246
PubMed:View item in PubMed

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