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The role of Irf6 in tooth epithelial invagination

Item Type:Article
Title:The role of Irf6 in tooth epithelial invagination
Creators Name:Blackburn, J. and Ohazama, A. and Kawasaki, K. and Otsuka-Tanaka, Y. and Liu, B. and Honda, K. and Rountree, R.B. and Hu, Y. and Kawasaki, M. and Birchmeier, W. and Schmidt-Ullrich, R. and Kinoshita, A. and Schutte, B.C. and Hammond, N.L. and Dixon, M.J. and Sharpe, P.T.
Abstract:Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikk{alpha} has been shown to play a critical role in controlling epithelial growth, since Ikk{alpha} mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikk{alpha} mutants, Irf6 mutant evagination occurs in a NF-{kappa}B-independent manner and shows the same molecular changes as those in Ikk{alpha} mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikk{alpha} and Irf6 mutant embryos.
Keywords:Ikk{alpha}, Irf6, Wnt, Incisor, Invagination, Epithelium, Tooth Development, Animals, Mice
Source:Developmental Biology
Publisher:Elsevier / Academic Press
Page Range:61-70
Date:1 May 2012
Official Publication:https://doi.org/10.1016/j.ydbio.2012.02.009
PubMed:View item in PubMed

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