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The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis

Item Type:Article
Title:The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis
Creators Name:Hohlfeld, R. and Meinl, E. and Weber, F. and Zipp, F. and Schmidt, S. and Sotgiu, S. and Goebels, N. and Voltz, R. and Spuler, S. and Iglesias, A.
Abstract:Autoimmune T cells play a key role as regulators and effectors of autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components or other locally expressed autoantigens enter the CNS and recognize their antigen(s) on local antigen-presenting cells. After local stimulation, the T cells produce a plethora of cytokines and inflammatory mediators that have profound effects on the local cellular environment, induce and recruit additional inflammatory cells, and contribute to myelin damage. An increasingly detailed knowledge of these processes will greatly facilitate the development of new immunotherapies. This article focuses on the role of T cells in MS. We provide a brief overview of the principles of T-cell immunology, discuss the experimental techniques available for studying T cells, address the role of T cells in the pathogenesis of MS, and highlight modern concepts for immunotherapy.
Keywords:Amino Acid Sequence, Autoimmunity, Cytokines, HLA Antigens, Molecular Sequence Data, Multiple Sclerosis, Myelin Proteins, T-Cell Antigen Receptors, T-Lymphocytes
Source:Neurology
ISSN:0028-3878
Publisher:Lippincott Wiliiams & Wilkins (U.S.A.)
Volume:45
Number:6 Suppl 6
Page Range:S33-S38
Date:June 1995
Official Publication:http://www.neurology.org/content/45/6_Suppl_6/S33.abstract
PubMed:View item in PubMed

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