Polyspecific immunoglobulins (IVIg) suppress proliferation of human (auto)antigen-specific T cells without inducing apoptosis

Item Type:	Article
Title:	Polyspecific immunoglobulins (IVIg) suppress proliferation of human (auto)antigen-specific T cells without inducing apoptosis
Creators Name:	Aktas, O. and Waiczies, S. and Grieger, U. and Wendling, U. and Zschenderlein, R. and Zipp, F.
Abstract:	Polyspecific immunoglobulins (IVIg) have been shown to reduce disease activity in multiple sclerosis (MS). To investigate the mechanisms of action of IVIg, we studied the impact of IVIg on growth and death (apoptosis) of human (auto)antigen-specific T cells. We observed a substantial suppression of proliferation of specifically activated T cells, in absence of caspase activation or DNA fragmentation. Further, neither susceptibility of T cells to undergo CD95-mediated apoptosis nor expression of apoptosis-blocking bcl-2 was modulated by IVIg. We conclude that IVIg may inhibit the reactivity of antigen-specific T cells in MS through suppression of proliferation rather than modulation of apoptosis.
Keywords:	Intravenous Immunoglobulins, Apoptosis, Proliferation, Multiple Sclerosis, Human
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	114
Number:	1-2
Page Range:	160-167
Date:	1 March 2001
Official Publication:	https://doi.org/10.1016/S0165-5728(01)00243-0
PubMed:	View item in PubMed

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