Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor

Item Type:	Article
Title:	Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor
Creators Name:	van Rooij, E. and Fielitz, J. and Sutherland, L.B. and Thijssen, V.L. and Crijns, H.J. and Dimaio, M.J. and Shelton, J. and De Windt, L.J. and Hill, J.A. and Olson, E.N.
Abstract:	Gender differences in cardiovascular disease have long been recognized and attributed to beneficial cardiovascular actions of estrogen. Class II histone deacetylases (HDACs) act as key modulators of heart disease by repressing the activity of the myocyte enhancer factor (MEF)2 transcription factor, which promotes pathological cardiac remodeling in response to stress. Although it is proposed that HDACs additionally influence nuclear receptor signaling, the effect of class II HDACs on gender differences in cardiovascular disease remains unstudied.
Keywords:	Estrogen Receptor, Cardiac Remodeling, Myocardial Infarction, Class II HDACs, Animals, Mice
Source:	Circulation Research
ISSN:	0009-7330
Publisher:	American Heart Association
Volume:	106
Number:	1
Page Range:	155-165
Date:	8 January 2010
Official Publication:	https://doi.org/10.1161/CIRCRESAHA.109.207084
PubMed:	View item in PubMed

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