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Thalamic control of cortical states

Official URL:https://doi.org/10.1038/nn.3035
PubMed:View item in PubMed
Creators Name:Poulet, J.F.A. and Fernandez, L.M.J. and Crochet, S. and Petersen, C.C.H.
Journal Title:Nature Neuroscience
Journal Abbreviation:Nat Neurosci
Volume:15
Number:3
Page Range:370-372
Date:22 January 2012
Keywords:Action Potentials, Afferent Pathways, Cortical Synchronization, Denervation, Electric Stimulation, Fourier Analysis, Neurons, Rhodopsin, Somatosensory Cortex, Transgenic Mice, Thalamus, Vibrissae, Wakefulness, Animals, Mice
Abstract:We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
ISSN:1097-6256
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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