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Axonal transcription factors signal retrogradely in lesioned peripheral nerve

Item Type:Article
Title:Axonal transcription factors signal retrogradely in lesioned peripheral nerve
Creators Name:Ben-Yaakov, K. and Dagan, S.Y. and Segal-Ruder, Y. and Shalem, O. and Vuppalanchi, D. and Willis, D.E. and Yudin, D. and Rishal, I. and Rother, F. and Bader, M. and Blesch, A. and Pilpel, Y. and Twiss, J.L. and Fainzilber, M.
Abstract:Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus.
Keywords:Axonal Transport, Dynein, Importin, Neuronal Injury, STAT, Animals, Mice, Rats
Source:EMBO Journal
Publisher:Nature Publishing Group
Page Range:1350-1363
Date:13 January 2012
Official Publication:https://doi.org/10.1038/emboj.2011.494
PubMed:View item in PubMed

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