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MicroRNA control in the immune system: basic principles

Item Type:Review
Title:MicroRNA control in the immune system: basic principles
Creators Name:Xiao, C. and Rajewsky, K.
Abstract:MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian immune system. Genetic ablation of the miRNA machinery, as well as loss or deregulation of certain individual miRNAs, severely compromises immune development and response and can lead to immune disorders like autoimmunity and cancer. Although individual miRNAs modulate protein output from hundreds of target genes, they may impact physiological processes by regulating the concentrations of just a few key cellular proteins that may be components of a single or of functionally interrelated pathways in a given cellular context.
Keywords:Gene Expression Regulation, Gene Regulatory Networks, Host-Pathogen Interactions, Immune System, MicroRNAs, Animals
Source:Cell
ISSN:0092-8674
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:136
Number:1
Page Range:26-36
Date:9 January 2009
Official Publication:https://doi.org/10.1016/j.cell.2008.12.027
PubMed:View item in PubMed

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