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PI3 kinase signals BCR-dependent mature B cell survival

Item Type:Article
Title:PI3 kinase signals BCR-dependent mature B cell survival
Creators Name:Srinivasan, L. and Sasaki, Y. and Calado, D.P. and Zhang, B. and Paik, J.H. and DePinho, R.A. and Kutok, J.L. and Kearney, J.F. and Otipoby, K.L. and Rajewsky, K.
Abstract:Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
Keywords:B-Lymphocytes, Cell Survival, Phosphatidylinositol 3-Kinases, B-Cell Antigen Receptors, Signal Transduction, Animals, Mice
Source:Cell
ISSN:0092-8674
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:139
Number:3
Page Range:573-586
Date:30 October 2009
Official Publication:https://doi.org/10.1016/j.cell.2009.08.041
PubMed:View item in PubMed

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