Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men

Item Type:	Article
Title:	Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men
Creators Name:	Steinbrecher, A. and Meplan, C. and Hesketh, J. and Schomburg, L. and Endermann, T. and Jansen, E. and Akesson, B. and Rohrmann, S. and Linseisen, J.
Abstract:	Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes.
Keywords:	Case-Control Studies, Europe, Genetic Predisposition to Disease, Genotype, Glutathione Peroxidase, Odds Ratio, Prostatic Neoplasms, Risk Factors, Selenium, Selenoproteins, Single Nucleotide Polymorphism, Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Source:	Cancer Epidemiology, Biomarkers & Prevention
ISSN:	1055-9965
Publisher:	American Association for Cancer Research
Volume:	19
Number:	11
Page Range:	2958-2968
Date:	November 2010
Official Publication:	https://doi.org/10.1158/1055-9965.EPI-10-0364
PubMed:	View item in PubMed

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