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| Item Type: | Article |
|---|---|
| Title: | 23Na magnetic resonance imaging of tissue sodium |
| Creators Name: | Kopp, C., Linz, P., Wachsmuth, L., Dahlmann, A., Horbach, T., Schoefl, C., Renz, W., Santoro, D., Niendorf, T., Müller, D.N., Neininger, M., Cavallaro, A., Eckardt, K.U., Schmieder, R.E., Luft, F.C., Uder, M. and Titze, J. |
| Abstract: | Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin. We compared (23)Na-MRI data with actual tissue Na(+) content measured by chemical analysis in animal and human tissue. We then quantified tissue Na(+) content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na(+) content in patients with aldosteronism compared with normal women and men. This tissue Na(+) was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible. |
| Keywords: | Aldosterone, MRI, Sodium, Hypertension, Animals, Mice, Rats |
| Source: | Hypertension |
| ISSN: | 0194-911X |
| Publisher: | American Heart Association |
| Volume: | 59 |
| Number: | 1 |
| Page Range: | 167-172 |
| Date: | January 2012 |
| Official Publication: | https://doi.org/10.1161/HYPERTENSIONAHA.111.183517 |
| PubMed: | View item in PubMed |
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