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A-kinase anchoring proteins as potential drug targets

Item Type:Review
Title:A-kinase anchoring proteins as potential drug targets
Creators Name:Troeger, J. and Moutty, M.C. and Skroblin, P. and Klussmann, E.
Abstract:A-kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents thereby directing pools of signalling components to defined locales. In particular, AKAPs mediate compartmentalisation of cAMP signalling. Alterations in AKAP expression and their interactions are associated with or cause diseases including chronic heart failure, various cancers and disorders of the immune system such as HIV. A number of cellular dysfunctions result from mutations of specific AKAPs. The link between malfunctions of single AKAP complexes and a disease makes AKAPs and their interactions interesting targets for the development of novel drugs.
Keywords:AKAP, PKA, Drug Targets, Small Molecules, Aquaporin, Heart Failure, Animals
Source:British Journal of Pharmacology
ISSN:0007-1188
Publisher:Wiley-Blackwell (U.K.)
Volume:166
Number:2
Page Range:420-433
Date:May 2012
Official Publication:https://doi.org/10.1111/j.1476-5381.2011.01796.x
PubMed:View item in PubMed

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