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Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction

Item Type:Article
Title:Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction
Creators Name:Sise, M.E. and Forster, C. and Singer, E. and Sola-Del Valle, D. and Hahn, B. and Schmidt-Ott, K.M. and Barasch, J. and Nickolas, T.L.
Abstract:BACKGROUND: Urinary tract obstruction (UTO) is a common problem that can lead to permanent loss of kidney function. Unilateral UTO may be difficult to diagnose. Urinary neutrophil gelatinase-associated Lipocalin (uNGAL) may identify unilateral and bilateral UTO. METHODS: Retrospective case-control study of patients undergoing hospital admission at three sites. UTO was determined by review of medical records and cases were matched to control patients. uNGAL was measured by immunoblot. RESULTS: Twenty-four unilateral UTO and 15 bilateral UTO cases were identified. Admission serum creatinine (sCr) (milligram per decilitre) was significantly higher in bilateral UTO, 2.0 (1.1-5.3), but not unilateral UTO, 1.1 (0.8-1.5), compared to controls, 0.9 (0.8-1.2). uNGAL (nanogram per millilitre) was significantly higher both in patients with bilateral UTO, 140 (40-450), and unilateral UTO, 50 (20-100), compared to controls, 20 (10-45). Discussion: uNGAL identifies kidney injury in unilateral and bilateral UTO even in the absence of an elevated sCr.
Keywords:Acute Kidney Injury, Biomarkers, Neutrophil Gelatinase-Associated Lipocalin, Obstructive Nephropathy, Urinary Tract Obstruction
Source:Nephrology Dialysis Transplantation
ISSN:0931-0509
Publisher:Oxford University Press (U.K.)
Volume:26
Number:12
Page Range:4132-4135
Date:December 2011
Official Publication:https://doi.org/10.1093/ndt/gfr569
PubMed:View item in PubMed

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