Helmholtz Gemeinschaft


New topics in bradykinin research

Item Type:Review
Title:New topics in bradykinin research
Creators Name:Maurer, M. and Bader, M. and Bas, M. and Bossi, F. and Cicardi, M. and Cugno, M. and Howarth, P. and Kaplan, A. and Kojda, G. and Leeb-Lundberg, F. and Loetvall, J. and Magerl, M.
Abstract:Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
Keywords:Angioedema, Bradykinin, C1 Esterase Inhibitor, Icatibant, Animals, Mice
Page Range:1397-1406
Date:November 2011
Official Publication:https://doi.org/10.1111/j.1398-9995.2011.02686.x
PubMed:View item in PubMed

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