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The role of blood flow and microRNAs in blood vessel development

Item Type:Article
Title:The role of blood flow and microRNAs in blood vessel development
Creators Name:Liu, D. and Krueger, J. and Le Noble, F.
Abstract:The circulatory system is the first organ system that develops during embryogenesis, and is essential for embryo viability and survival. Crucial for developing a functional vasculature are the specification of arterial-venous identity in vessels and the formation of a hierarchical branched vascular network. Sprouting angiogenesis, intussusception, and flow driven remodeling events collectively contribute to establishing the vascular architecture. At the molecular level, arterial-venous identity and branching are regulated by genetically hardwired mechanisms involving Notch, vascular endothelial growth factor and neural guidance molecule signaling pathways, modulated by hemodynamic factors. MicroRNAs are small, non-coding RNAs that act as silencers to fine-tune the gene expression profile. MicroRNAs are known to influence cell fate decisions, and microRNA expression can be controlled by blood flow, thus placing microRNAs potentially at the center of the genetic cascades regulating vascular differentiation. In the present review, we summarize current progress regarding microRNA functions in blood vessel development with an emphasis on studies performed in zebrafish and mouse models.
Keywords:microRNA, Blood Vessel, Development, Endothelial Cell, Smooth Muscle Cell, Animals, Mice, Zebrafish
Source:International Journal of Developmental Biology
ISSN:0214-6282
Publisher:UBC Press (Spain)
Volume:55
Number:4-5
Page Range:419-429
Date:2011
Official Publication:https://doi.org/10.1387/ijdb.103220dl
PubMed:View item in PubMed

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