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Functional evidence of post-transcriptional regulation by pseudogenes

Item Type:Review
Title:Functional evidence of post-transcriptional regulation by pseudogenes
Creators Name:Muro, E.M. and Mah, N. and Andrade-Navarro, M.A.
Abstract:Pseudogenes have been mainly considered as functionless evolutionary relics since their discovery in 1977. However, multiple mechanisms of pseudogene functionality have been proposed both at the transcriptional and post-transcriptional level. This review focuses on the role of pseudogenes as post-transcriptional regulators. Two research lines have recently presented strong evidence of their potential function as post-transcriptional regulators of the corresponding parental genes from which they originate. First, pseudogene genomic sequences can encode siRNAs. Second, pseudogene transcripts can act as indirect post-transcriptional regulators decoying ncRNA, in particular miRNAs that target the parental gene. This has been demonstrated for PTEN and KRAS, two genes involved in tumorigenesis. The role of pseudogenes in disease has not been proven and seems to be the next research landmark. In this review, we chronicle the events following the initial discovery of the 'useless' pseudogene to its breakthrough as a functional molecule with hitherto unbeknownst potential to influence human disease.
Keywords:Pseudogenes, ncRNA, Natural Antisense Transcripts, siRNA, miRNA, Animals, Mice
Source:Biochimie
ISSN:0300-9084
Publisher:Elsevier (France)
Volume:93
Number:11
Page Range:1916-1921
Date:November 2011
Official Publication:https://doi.org/10.1016/j.biochi.2011.07.024
PubMed:View item in PubMed

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