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Forkhead transcription factors in ovarian function

Item Type:Review
Title:Forkhead transcription factors in ovarian function
Creators Name:Uhlenhaut, N.H. and Treier, M.
Abstract:Since the discovery of the conserved forkhead DNA binding domain more than 20 years ago, members of the forkhead or FOX family of transcription factors have been shown to act as important regulators of numerous developmental and homeostatic processes. The human genome contains 44 forkhead genes, several of which have recently been reported to be essential for female fertility. In this review we will highlight the roles of specific FOX proteins in ovarian folliculogenesis and present our current understanding of their molecular function. In particular, we will describe what we have learned from loss-of-function studies using mouse models as well as human genetics and illustrate how different stages of folliculogenesis, both in oocytes and in somatic granulosa and theca cells, are regulated by FOXC1, FOXL2, and FOXO subfamily members.
Keywords:Ovary, Transcription Factors, Disease Models, Female Infertility, Forkhead Factors, Animals, Mice
Publisher:Bio Scientifica
Page Range:489-495
Date:October 2011
Official Publication:https://doi.org/10.1530/REP-11-0092
PubMed:View item in PubMed

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